Endocrine Abstracts

Premature infants are at significant risk of reduced bone mineral content and osteopenia. Inadequate phosphate and calcium uptake in-utero followed by poor postnatal intake in the presence of high growth velocity leads to metabolic bone disease in premature babies. It is not due to vitamin D or parathyroid hormone deficiency.There is no national or international consensus on how to prevent or manage this condition leading to varied practice across the di...

Prepubertal gynaecomastia may be due to increased oestrogen resulting from excessive aromatase activity in extra glandular tissues. CYP19A1 gene on chromosome 15q21.2 encodes aromatase, the key enzyme for oestrogen biosynthesis. Tissue-specific promoters regulating the expression of aromatase activity have been demonstrated in placenta, ovary, testes, brain, skin fibroblasts and adipocytes. Mutations involving aromatase cytochrome P450 (P450arom) have been reported ...

Purpose: To identify predictive biomarkers of recurrence in NFPTs, we used heat shock protein profiling approach to correlate protein expression profiles with tumor recurrence. Heat shock proteins (HSPs) are synthesized by cells in response to various stress conditions, including carcinogenesis. The expression of HSPs in tumors has been implicated in the regulation of apoptosis. In the current study, we attempted to clarify the significance of HSPs in NFPTs and their correlati...

Background: The geographical difference in presentation of primary hyperparathyroidism (PHPT) is well known however, there is spare literature on influence of age and gender on presentation of PHPT.Objective: To study the effect of age and gender on clinical and biochemical presentation of PHPT.Method: This is a retrospective analysis of 184 histopathologically proven PHPT patients between March 1990 and March 2010 from a single ce...

Case report;A 42-year-old male presented with headache, coarserning of facial features, enlargement of body parts of 2 years duration. There was no visual disturbance. His height was 168cms, wt 71kg and BMI of 25Kg/ per met square.He was normotensive .Biochemical and hormonal profile revealed he was euglycemic, euthyroid, serum cortisol(am)280nmo/lit(normal 450-700nmo/lit) non suprresible GH values of 46 ng/ml with 75gms of oral glucose (normal< 1 ng ...

Case report;A 42-year-old male presented with headache, coarserning of facial features, enlargement of body parts of 2 years duration. There was no visual disturbance. His height was 168cms, wt 71kg and BMI of 25Kg/ per met square.He was normotensive .Biochemical and hormonal profile revealed he was euglycemic, euthyroid, serum cortisol(am)280nmo/lit(normal 450-700nmo/lit) non suprresible GH values of 46 ng/ml with 75gms of oral glucose (normal< 1 ng ...

Background: Diabetic striatopathy (DS) is a rare dyskinetic syndrome associated with acute decompensated hyperglycemia that commonly presents as hemichorea-ballism. Its natural history following resolution of the hyperglycemic crisis is not well delineated.Methods: The study was a prospective evaluation of the long-term clinico-radiological outcomes of patients presenting with DS. Neuroimaging (CT/MRI) was performed at baseline and follow-up (>3 mont...

Background: Indeterminate thyroid nodules pose a diagnostic dilemma and the patients often undergo unnecessary surgeries or repeat surgery. Currently different molecular methods for detection of driver mutations are being used for better characterisation of these nodules. These methods are costly and not widely available all over the world. Currently use of liquid biopsy by measurement of cell-free DNA (cfDNA) levels from plasma has been useful in diagnosis and follow up of ca...

Context: Recurrent Pregnancy Loss (RPL), defined as two or more consecutive pregnancy losses, is a serious reproductive problem, affecting 1–5 per cent of reproductive-age women. Although a high percentage (7.46%) of RPL cases are reported from India, scanty reports are available on the molecular mechanisms associated with RPL susceptibility in the population of the north-eastern state of Assam. Hormonal imbalances are a major cause of recurrent pregnancy loss. Recent stu...

Introduction: Molecular testing is being increasingly used to detect malignancy in indeterminate thyroid nodules (Bethesda 3 & 4) which pose diagnostic dilemma. Long non-coding RNAs are crucial for metastasis, angiogenesis, and tumour growth of various cancers. Clinical utility of plasma lncRNAs as non-invasive diagnostic markers for thyroid cancer especially in indeterminate nodule remains unexplored.Methodology: We selected lncRNAs relevant to thyr...